ED₅₀ ± S.E.M.

Assay

Control

1 day

3 days

L-NAME 1

L-NAME 5

AMG 50

AMG 100

WT

20.1 ± 0.45

17.08 ± 2.24

19.13 ± 2.43

19.10 ± 1.09

21.55 ± 2.51

20.8 ± 3.50

19.50 ± 3.80

TF

N/A

61.27 ± 5.92

55.26 ± 7.74^*

118.23 ± 5.8^*

97.92 ± 3.89^▲Ë

125.80 ± 5.78^*

130.65 ± 11.08^▲

FP

Phase I

140.50 ± 6.55

35.11 ± 4.88

31.01 ± 5.10

92.98 ± 0.78^*

82.66 ± 5.81^▲

110.24 ± 12.36^*

125.57 ± 8.59^▲Ò

Phase II

165.00 ± 7.50

26.31 ± 5.29

17.37 ± 1.36^*

38.12 ± 3.71^*

75.64 ± 6.32^▲Ë

135.84 ± 9.87^*

158.39 ± 8.21^▲Ò

OF,

Phase I

124.50 ± 4.55

14.50 ± 2.34

13.06 ± 0.40

68.56 ± 8.93^*

65.78 ± 3.12^▲

112.53 ± 5.37^*

104.57 ± 9.87^▲

Phase II

158.00 ± 4.15

11.68 ± 1.01

10.71 ± 1.33

71.54 ± 5.75^*

85.22 ± 5.45^▲Ë

139.71 ± 8.76^*

157.25 ± 10.67^▲Ò

HP

19.50 ± 1.50

48.94 ± 6.79

36.83 ± 1.81^*

28.57 ± 8.12^*

29.36 ± 6.78

31.81 ± 5.91^*

42.54 ± 5.62^▲Ò